Which miRVEL library prep kit should I choose?

Both miRVEL Profiling and Discovery Kits enable small RNA library generation from total or enriched small RNAs.

The choice of the kit is mainly based on the RNA quality, RNA input amount and downstream application(s).

The miRVEL Discovery kit is ideal for advanced sRNA discovery studies and for biofluid samples as well as low-quality and/or low-input amount RNA. Built-in UMIs allow for the removal of PCR duplicates for an accurate quantification of sRNA molecules in each sample and 10 nt UDIs offer a high-level of multiplexing (up to 120 samples).

The miRVEL Profiling Kit is a cost-effective solution perfectly suited for sRNA profiling, RNAi and small RNA-driven host-defense mechanisms studies. The protocol allows for preparation of sRNA libraries from a wide input range via a quick and easy workflow (with only one purification step) with unique dual indexing (8nt UDIs) for multiplexed sequencing.