Does RiboCop for Yeast efficiently deplete rRNA from low quality RNA?

Yes.

RiboCop for Yeast reduces rRNA reads in low quality RNA (RIN ~2) to 2 - 5% over a broad range of input amounts (10 - 1,000 ng).

NOTE: Depletion rates may vary depending on the quality of the RNA and purity of the sample. Contaminants, such as salts, metal ions, and organic solvents, may have a negative impact on the efficiency of the protocol.